Scientific American has an article that ties an ancient gene to our obesity issues, but it is behind a pay wall, so this site has a nice summary of the part that concerns this thread.
This is the money shot:
The Scientific American article centers around a gene that produces an enzyme called uricase (which exists to dispose of excess uric acid) and mutated before humans split off from the great apes; the mutation crippled prodution of the enzme. Most animals have it, humans and the great apes don't. Way back then the world was cooling and food was getting scarce, so a mutation which caused more fat production was a survival trait.
We do have choice, but circumstances make some choices harder than others.
This is the money shot:
In the last half century we have found a way to both easily make sugar from sugar cane and beets and to convert starch from corn to fructose with a simple enzyme reaction. Sugar has become cheap and plentiful. Sugar is now added to many of our foods and our daily consumption has risen from 5 pounds to 150 pounds a year in the last century. This over consumption of fructose leads to higher blood uric acid levels. High uric acid levels block the hormone leptin. A lack of leptin stops people from feeling full and that leads to weight gain and metabolic syndrome.
We do have choice, but circumstances make some choices harder than others.
Comment