It's inconsistent with science because you have provided no evidence to support the proposition.
So the onus is on you to show which fundamental biological principle this contradicts. I can only think of one, that evolution is random, and as you've stated, that's not really a biological principle.
You would be better served by thinking not in terms of randomness, but in terms of variation.
If evolution is not random, then what's the issue with God directed evolution, other then atheist philosophy which biases your perception? Going into a god of the gaps argument has jack-all to do with scientific principles.
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