Announcement

**Ramo** · October 7, 2002, 18:50

I have allergies to just about everything (some cats, lots of pollin, most fish, lots of miscellaneous chemicals - including tobacco smoke, etc.).
I have asthma (although it's been a couple years since I've had an attack).
I'm out of shape (but I've been working on that the past couple weeks).

**Asher** · October 7, 2002, 19:00

Mentally:

**Gangerolf** · October 7, 2002, 19:09

near-sightedness

unexplainable nose bleeding

sleepwalking

semi-alcoholism

dandruff

cold fingers

**DinoDoc** · October 7, 2002, 19:10

Originally posted by chegitz guevara
RJ, what I mean by an allergy to extreme cold is that I break out in hives when exposed to cold. And me living in frigid Chicago for the next 20 years.

Strange.

**Flubber** · October 7, 2002, 19:25

Lets see

mild asthma
near-sighted
alpha thalassemia ( assymptomatic but interesting)
Translocation of the 4 and 10 chromosomes ( no symptoms known but the medical types really have no idea what effects it may have)

edit -spelling

**Provost Harrison** · October 7, 2002, 19:36

Chromosomal mutations? Interesting. So 4 and 10 translocation is harmless? There are some which are harmful. It is believed that it effects patterns of transcription in chromosomal material. Genes 'switch' on and off depending on point in the cell cycle, type of cell, stage in development, etc, etc. Now genes occur in blocks and are switched on and off in bulk, and there will only be one site for the initiation of transcription. Now if there is a translocation with the origin of translocation in the middle of one of those regions, you could end up moving a block of genes to a region where it will be transcribed in a different pattern as it will be dependent on a different set of transcriptional factors and promotors, and the same will happen to the other set of genes.

Hence you will be transcribing and translating proteins that have could have a dramatic effect on the cell when they shouldn't be active at that point, and not transcribing others when they are needed.

I really need to draw a diagram for this

...so is though

**Flubber** · October 7, 2002, 19:47

Provost

so far they have identified something like 6 people in our family with what they call "balanced" translocation of 4 and 10-- I have the documents somewhere that indicated the break points.

They call it balanced as there seems to be no genetic material missing, simply some material has switched places. We have been seeing geneticists to determine the impacts and so far they just don't know although they say we are at increased chance for various birth defects -- (although the amount of material that is switched is so great that they believe any child of mine that had an "unbalanced" situation, would not survive implantation let alone be viable to be carried to term. ) Also of the 6 identified carriers, only 2 were women and neither of them has successfully carried a pregnancy to term. All 4 men have fathered children and it appears to be about 50/50 whether such children have " normal" chromosomes or carry the translocation.

**Provost Harrison** · October 7, 2002, 19:54

Yes, the genome is a very complicated thing. We may know it's sequence, and what gene does what. But that's the basics of the genome. It's not a linear storage system, unlike a hard drive. It's an active system, changing through methylation, transcription factors binding depending on signals within the cell and dependent on cell cycle.

The problem is, you can't understand the complexity of the genome and it's patterns of transcription and how it changes without understanding the functioning of the entire organism, and vice versa.

The genome project is the tip of the iceberg, there is so much to understand about the 'mechanics' of the genome. How this break affects an organism is unknown, because even the slight alteration of one gene, or the points at which it is expressed has a vast effect. It is like changing a cog inside a clock...the effect could be dramatic on the large scale...

**Skanky Burns** · October 7, 2002, 19:56

Back pain
Underweight

Not too bad I guess.

**Provost Harrison** · October 7, 2002, 19:59

Hey, a compromise Skanky, you have some of my weight and we'd both balance out at normal

**Evil Knevil** · October 7, 2002, 20:24

Blind as a bat

(seriously, thanks to astigmatism the widest part of my glasses is about as thick as 2x2p coins). Still too stubborn to wear glasses though!

Almost completely deaf in my right ear.

10 years ago my (ex)girlfriend fired a rifle next to my head on a shooting range; before I'd put my mufflers on, stupid *****. Burst eardrum and remained so infected and weak I find it hard to hear on that side, dammit.

Back injury.

One of my old (menial, predegree)jobs had me working behind a till at a petrol station, as well as putting together newspapers, which meant running backwards and forwards with heavy bundles of newspaper suppliments, usually taller than me, trying to back to the till asap to serve ugly scotsmen. Needless to say I put my back out, and it still gives me gyp when I do heavy lifting.

Appart from that lot (and acid flashbacks) I'm in a rude state of health, at 29!

Provost, once had a wart on the inside of my nose! How the hell it got there, God only knows...

**Skanky Burns** · October 7, 2002, 20:29

If only it were that simple.

**Evil Knevil** · October 7, 2002, 20:30

I dunno, a hosepipe, a vaccum, few incisions. Bobs yer uncle.

**Seneca** · October 7, 2002, 20:35

Good god, I must get my jabs before the next Poly meet...

**devilmunchkin** · October 8, 2002, 02:18

acne..bad bad bad bad......*shudders*
asthma....though it had faded away for the most part
depression/bipolardisorder/borderline personality disorder...i'm a nut!

slightly hard of hearing
migraines
chest pains associated with stress

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