One of the advantages of GEs is you can actually avoid great artist pollution by building, say, the Parthenon or Sistine Chapel in a border city that could use the culture boost.
But I don't think that running a mixed wonder GP farm in the midgame is that bad. The artist pollution from National Epic is tolerable when the chances of generating a GA are down to 10-12% due to multiple sources of more useful GPs, in particular the Great Library which counts as 3 scientist sources. It's harder to get the percentage lower than that with a specialist city (unless you have a really good food site and can run Caste System.) Also, it's easier to build wonders in one high production city (often the capital) that already finished its other essential infrastructure than to distribute them around, unless you have a lot of forest. I do agree it's generally worth isolating the artist wonders in a non-cultural game if it can be done without too much hassle though.
On an unrelated note, one irritating thing is that National Epic + Globe Theatre looks like such a good combination on paper for a high food, specialist based GP farm, but building both introduces enough artist point pollution to make it not worthwhile unless aiming for a cultural victory.
But I don't think that running a mixed wonder GP farm in the midgame is that bad. The artist pollution from National Epic is tolerable when the chances of generating a GA are down to 10-12% due to multiple sources of more useful GPs, in particular the Great Library which counts as 3 scientist sources. It's harder to get the percentage lower than that with a specialist city (unless you have a really good food site and can run Caste System.) Also, it's easier to build wonders in one high production city (often the capital) that already finished its other essential infrastructure than to distribute them around, unless you have a lot of forest. I do agree it's generally worth isolating the artist wonders in a non-cultural game if it can be done without too much hassle though.
On an unrelated note, one irritating thing is that National Epic + Globe Theatre looks like such a good combination on paper for a high food, specialist based GP farm, but building both introduces enough artist point pollution to make it not worthwhile unless aiming for a cultural victory.
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