Assuming they know exactly where all of them are.
Indeed...
Looking through the Power Point presentation given in that Atlantic Monthly article, I saw something interesting. There's apparently a theater missile defense system (THAAD) that supposedly can shoot down Iranian missiles in their midcourse phase. Once again though, you have to worry about its effectiveness when one mistake may mean the nuclear destruction of Tel Aviv. You could have the USAF blow up all the launchers they could and use THAAD to take out any missiles that managed to survive and be launched after the fact, but there's still an awfully big risk that something might get through.
All in all, we should all just hope that Iran doesn't have a deliverable nuke yet.
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