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Potentially new, HORRENDOUS news... faster infecting HIV
Originally posted by Dissident
how hard is it to use a ****ing condom?
It's reasons like this why this disease spreads and becomes worse.
No its not there are some people out there that go out knowing they have the disease and do what they can to share the wealth such as getting past the donating blood screens. There are more ways to transfer this disease then im willing to type.
When you find yourself arguing with an idiot, you might want to rethink who the idiot really is. "It can't rain all the time"-Eric Draven
Being dyslexic is hard work. I don't even try anymore.
"I hope I get to punch you in the face one day" - MRT144, Imran Siddiqui
'I'm fairly certain that a ban on me punching you in the face is not a "right" worth respecting." - loinburger
Originally posted by VJ
If this is gonna be any similar to what has happened to antibiotics, the virus is going to become resistant eventually to those drugs, too; am I correct?
Mmm, in my admittedly limited understanding, these drugs don't work on the virus directly as such, they interfere with the cell's ability to transcribe RNA, effectively making the cell ignore the virus's instructions. The nasty side effects of anti-retrovirals are due to the natural consequences of screwing with biology on a cellular level...they're only valuable as the lesser of two evils. So I don't get how people could be "disguising the symptoms" with anti-retrovirals and going out and having sex. I'd read that the drugs have rather plain side effects, including big unsightly swellings, and are sufficiently non-fun to live with that they won't put you in the mood for sex. Fo gigure.
Anyway, the reason bacteria become resistant to antibiotics, which don't do a thing against viruses, is that they directly attack the microbe's function, which the germs adapt to as all populations will to attacks. Vaccinations, the traditional weapon against viruses, essentially train the host to recognize a virus by pitting it against a harmless relative, kind of like the way people once trained new attack dogs by pitting them against old, toothless ones. Anti-viral drugs are a fairly unusual thing, given the primitive nature of viruses; my intuition would be that the virus would have to basically reinvent the pathogenic wheel in order to get around a transcription blocker. But again, I'm not a biologist.
Well a lot of the antiviral drugs inhibit reverse transcriptase. They don't interfere with your own cells ability to transcribe but the viruses ability to transcribe RNA to DNA - the only place where such a transaction occurs. Drugs like AZT block reverse transcriptase and thus stop the virus being able to generate a DNA version of it's genome and integrating it into the host cell.
Now for this to be a different version as described it would somehow have to be triggered by a different mechanism suggesting that it's DNA would be integrated into a different part of the human genome, and that it's reverse transcriptase is somehow different in specificity.
Oh, the reason that reverse transcriptase inhibitors are dangerous is because that they can sometimes be integrated into the genome via replication, and thus mutation can occur...
Speaking of Erith:
"It's not twinned with anywhere, but it does have a suicide pact with Dagenham" - Linda Smith
Originally posted by Kuciwalker
Wait, they deliver reverse transcriptase inhibitors as a virus! If they only give you the inhibitor, then it couldn't be integrated into the genome.
What? Reverse transcriptase inhibitors are intaken (often orally), and as it is an irreversible competitive inhibitor to thymidine it blocks up the active site of reverse transcriptase. As it is all statistical due to the relative concentrations, it won't stop the virus but significantly slow it down.
There are also interferons which can be administered. They are usually secreted when a cell is in distress which tells neighbouring cells to 'brace themselves' for a viral attack by slowing down rates of protein synthesis. The logic behind this is that if the rate of protein synthesis from mRNA then the virus is slowed because it will take much longer to produce viral protein components. And give the immune system a better chance against it.
Originally posted by Kuciwalker
Reverse transcriptase is an enzyme. Protein can't be integrated into the genome. The enzyme itself'll break down after a while.
Are you actually listening? Reverse transcriptase is an enzyme. Enzymes are proteins which are coded for in DNA, and the DNA which a retrovirus integrates into the human genome has to be reverse transcribed from it's RNA which the viral capsid carries. If you really want to go all round on genetics with me kid, let's go...
Speaking of Erith:
"It's not twinned with anywhere, but it does have a suicide pact with Dagenham" - Linda Smith
Okay, can you two agree on a reason why the drugs cause all those nasty side effects? I know those exist, and from what I hear not just as a risk of *possible* mutation. Those side effects have been a huge weapon in South Africa's suicidal propaganda campaign against western medicine for AIDS, which is why so many Africans are trying to cure themselves by drinking water mixed with wheat germ or some crap like that.
Originally posted by Provost Harrison
Are you actually listening? Reverse transcriptase is an enzyme. Enzymes are proteins which are coded for in DNA, and the DNA which a retrovirus integrates into the human genome has to be reverse transcribed from it's RNA which the viral capsid carries. If you really want to go all round on genetics with me kid, let's go...
I meant to say the inhibitor. And your original quote was
Oh, the reason that reverse transcriptase inhibitors are dangerous is because that they can sometimes be integrated into the genome via replication, and thus mutation can occur...
The inhibitors would have to be delivered by a virus (which incidentally would have to use reverse transcriptase) for them to be integrated into the genome.
You're going to die anyway, probably, and the increased speed won't probably decrease the chance of treatments working. The worst epidemics are the ones where the victim lasts as long as possible - the rest burn themselves out, or can be contained. This could lead to fewer deaths.
You're going to die anyway, probably, and the increased speed won't probably decrease the chance of treatments working. The worst epidemics are the ones where the victim lasts as long as possible - the rest burn themselves out, or can be contained. This could lead to fewer deaths.
To clarify: I was speaking of those who think that this means that "******s" will die quicker and get what they "deserve".
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