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Peculiar Diseases Of The Finns

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  • #1

    Peculiar Diseases Of The Finns

    There was a fascinating couple of pages in the book The Sequence' by Kevin Davies

    THE SEQUENCE is the definitive account of what has been described as the single most important scientific breakthrough of modern times - the elucidation of mankind's complete genetic script. It is a story in which science, politics, business and society meet head on. At its heart is the race between the $3 billion Human Genome Project led by the brilliant geneticist Francis Collins, and a renegade biotech company founded by the scientist-entrepreneur J. Craig Venter. This riveting book takes the reader into the labs and lives of these and other researchers who in late 2000 completed the first draft of the human genome. Regardless of who 'won' the race, the stakes involved in this remarkable work are staggeringly high.
    The Sequence : Inside the Race for the Human Genome
    http://www.goodreads.com/book/show/430793.The_Sequence
    Good clean copy - as new.


    which I read just after Christmas. I was immediately reminded of Laz's 'Evil Finns' threads...

    Chapter Six: Treasures Of The Lost Worlds'

    By the early 1970s, genetecists recognized that Finland was unusually fertile ground for the study of human genetics. All told, more than thirty genetic diseases are more common in Finland than in other populations, whereas other disorders that afflict large numbers of Europeans, such as phenylketonuria and cystic fibrosis, are scarce or absent.

    [...]

    Some of these disorders, such as Imerslund-Grasbeck syndrome and Mulibrey nanism, are obscure even by the standards of card-carrying geneticists.
    The disorders can show up in discrete groupings- amyloidosis tends to be grouped in the southeast, retinoschisis in the southwest, and so on.


    Imerslund-Grasbeck syndrome:

    Imerslund-Gräsbeck syndrome (selective vitamin B12 malabsorption with proteinuria) - Orphanet Journal of Rare Diseases
    http://www.ojrd.com/content/1/1/17
    Imerslund-Gräsbeck syndrome (IGS) or selective vitamin B12 (cobalamin) malabsorption with proteinuria is a rare autosomal recessive disorder characterized by vitamin B12 deficiency commonly resulting in megaloblastic anemia, which is responsive to parenteral vitamin B12 therapy and appears in childhood. Other manifestations include failure to thrive and grow, infections and neurological damage. Mild proteinuria (with no signs of kidney disease) is present in about half of the patients. Anatomical anomalies in the urinary tract were observed in some Norwegian patients. Vitamin B12 absorption tests show low absorption, not corrected by administration of intrinsic factor. The symptoms appear from 4 months (not immediately after birth as in transcobalamin deficiency) up to several years after birth. The syndrome was first described in Finland and Norway where the prevalence is about 1:200,000. The cause is a defect in the receptor of the vitamin B12-intrinsic factor complex of the ileal enterocyte. In most cases, the molecular basis of the selective malabsorption and proteinuria involves a mutation in one of two genes, cubilin (CUBN) on chromosome 10 or amnionless (AMN) on chromosome 14. Both proteins are components of the intestinal receptor for the vitamin B12-intrinsic factor complex and the receptor mediating the tubular reabsorption of protein from the primary urine. Management includes life-long vitamin B12 injections, and with this regimen, the patients stay healthy for decades. However, the proteinuria persists. In diagnosing this disease, it is important to be aware that cobalamin deficiency affects enterocyte function; therefore, all tests suggesting general and cobalamin malabsorption should be repeated after abolishment of the deficiency.


    Mulibrey nanism:

    Medical Professional Hub
    http://www.patient.co.uk/doctor/Mulibrey-Nanism.htm
    Our medical professional hub provides a wealth of professional articles, medical tools, and resources written for GPs and other health professionals to use.



    It's a great read which I recommend to anyone interested in the Human Genome projects or genetics or popular science.
    Vive la liberte. Noor Inayat Khan, Dachau.

    ...patriotism is not enough. I must have no hatred or bitterness towards anyone. Edith Cavell, 1915
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  • #2
    Asher got us all involved in grid computing about 8 years ago to unlock the Human Genome I believe. Was a world community grid project.

    So the real story is that Poly is the sharp edge of the blade here.
    "I am sick and tired of people who say that if you debate and you disagree with this administration somehow you're not patriotic. We should stand up and say we are Americans and we have a right to debate and disagree with any administration." - Hillary Clinton, 2003

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    • #3
      Hmm, maybe they can find the so-called "Evil gene."
      “As a lifelong member of the Columbia Business School community, I adhere to the principles of truth, integrity, and respect. I will not lie, cheat, steal, or tolerate those who do.”
      "Capitalism ho!"

      Comment

      • #4
        Originally posted by DaShi View Post
        Hmm, maybe they can find the so-called "Evil gene."
        Alas, evil jeans have been found:

        Click image for larger version Name: mullet1.jpg Views: 1 Size: 35.9 KB ID: 9094719
        Vive la liberte. Noor Inayat Khan, Dachau.

        ...patriotism is not enough. I must have no hatred or bitterness towards anyone. Edith Cavell, 1915

        Comment

        • #5
          Originally posted by molly bloom View Post
          Alas, evil jeans have been found:

          [ATTACH=CONFIG]173487[/ATTACH]
          Can't tell if tattoo is photoshopped.
          "I hope I get to punch you in the face one day" - MRT144, Imran Siddiqui
          'I'm fairly certain that a ban on me punching you in the face is not a "right" worth respecting." - loinburger

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          • #6
            Originally posted by MRT144 View Post
            Can't tell if tattoo is photoshopped.
            Rather wish the hair were.
            Vive la liberte. Noor Inayat Khan, Dachau.

            ...patriotism is not enough. I must have no hatred or bitterness towards anyone. Edith Cavell, 1915

            Comment

            • #7
              1) I'm a Finn, 2) I am filled with diseases, 3) I'm drunk at the moment, 4) 3 is true because 2. Is 2 true because 1? I don't know. All I know is I don't like most people, and I've come less prone to "you have to get along with everyone". No I don't. I don't have to deal with lots of people. Just the people I like. Others can do something else. They probably wouldn't like me either so hey, everybody wins. I don't know if I want to fight or just to be loved. Which one is stronger.... the desire to be hugged and have an opportunity to regress into some sort of a baby or just bury the pain and fight idiots.
              In da butt.
              "Do not worry if others do not understand you. Instead worry if you do not understand others." - Confucius
              THE UNDEFEATED SUPERCITIZEN w:4 t:2 l:1 (DON'T ASK!)
              "God is dead" - Nietzsche. "Nietzsche is dead" - God.

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              • #8
                Pekka
                To us, it is the BEAST.

                Comment

                • #9
                  NEW RULE:

                  Drink more beer. Beer until my laptop runs out of battery... 15 % remaining...
                  In da butt.
                  "Do not worry if others do not understand you. Instead worry if you do not understand others." - Confucius
                  THE UNDEFEATED SUPERCITIZEN w:4 t:2 l:1 (DON'T ASK!)
                  "God is dead" - Nietzsche. "Nietzsche is dead" - God.

                  Comment

                  • #10
                    do you finns have wall based power outlet technology yet?
                    To us, it is the BEAST.

                    Comment

                    • #11
                      Not yet. For that we would need walls.
                      In da butt.
                      "Do not worry if others do not understand you. Instead worry if you do not understand others." - Confucius
                      THE UNDEFEATED SUPERCITIZEN w:4 t:2 l:1 (DON'T ASK!)
                      "God is dead" - Nietzsche. "Nietzsche is dead" - God.

                      Comment

                      • #12
                        just build them out of used sauna stones
                        To us, it is the BEAST.

                        Comment

                        • #13
                          I love you, Sava.
                          In da butt.
                          "Do not worry if others do not understand you. Instead worry if you do not understand others." - Confucius
                          THE UNDEFEATED SUPERCITIZEN w:4 t:2 l:1 (DON'T ASK!)
                          "God is dead" - Nietzsche. "Nietzsche is dead" - God.

                          Comment

                          • #14
                            To us, it is the BEAST.

                            Comment

                            • #15
                              I just saw this

                              Someone made a Finland survival sim

                              To us, it is the BEAST.

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