Waiting until Ecology (Mass Transit) to get Sanitation (Hospitals) can really cut down on pollution problems. I usually don't space my cities too far apart anyways, so in order to not have to deal with pollution I just wait and let my cities stay at size 12. I still end up using just about every tile anyways.
The only exception would be in scoring games, where building hospitals as early as possible really can make a difference.
The only exception would be in scoring games, where building hospitals as early as possible really can make a difference.
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