Probably you will already have the game won or nearly so by the time you get to cybernetic. There are many SE combinations (too many to be exhaustive about in a reply), and many of them are useful or at least workable. To get the most out of them, consider a couple of factors:
1) When will I have the tech to use a particular setting, and what will my needs be by that time?
2) Which settings will accentuate my strengths or minimize my deficiencies?
Support is important early on (before clean technology) if you plan on building a lot of units per base.
Morale can give you a qualitative edge over your opponents, and can be particularly important for psi-combat.
Economy (especially +2 or better) can have a huge impact upon the amount of energy you produce.
Efficiency determines how much of that energy you keep, and also how many drones your bases produce.
Planet determines how much pollution you produce for a given mineral output, and also effects your combat chances with native lifeforms.
Growth is pretty self explanetary, but keep in mind if you manage to get +6 growth, your bases will grow 1 population per turn as long as you have at least 2 extra food.
Now keep in mind that all of these factors are modified to some extent by faction bonuses, facilities, special projects etc. All of this complexity is daunting as hell at first (or in my case after quite a few games when I began to realize that I was not really mastering the game, but adding more techniques to play it) but this is what makes this game so great. There are so many ways to play it, and play it well.
If you haven't seen it already, I suggest having a look at Vel's strategy guide. (Look for the topic 'Signed, Sealed, and Delivered') It is a fairly comprehensive guide to the game, and it contains useful tips for playing each faction. You may also want to peruse some of the threads here (be selective, there are a million of them) as there are some truly excellent players who are (or have) posting excellent strategies. Welcome to what may well become an obsession.